Best of
Best Supplements Where Drug Interactions Matter Most
Last updated 2026-07-02· Last reviewed 2026-07-02· 1 min read
Reviewed by the Ultimate Longevity Bible editorial team. Educational reference — not medical advice. See disclaimer.
Bleeding risk (stop before surgery / with anticoagulants)
- Fish oil / omega-3 at high doses.
- Ginkgo biloba.
- Garlic at high supplement doses.
- Ginseng.
- Turmeric / curcumin at high doses.
- Vitamin E at high doses (>400 IU).
Hypoglycaemia risk (caution with diabetes drugs)
- Berberine (potent — can amplify metformin, sulfonylureas, insulin).
- Bitter melon.
- Chromium picolinate.
- Fenugreek.
Sedation risk (with benzodiazepines, sleep aids)
- Melatonin (usually benign but potentiating).
- Valerian.
- Kava.
- CBD.
Serotonin syndrome risk (with SSRIs, SNRIs, MAOIs)
- 5-HTP.
- St John's wort.
- SAM-e.
- Tryptophan.
Blood pressure interactions
- Licorice root (raises BP; watch with hypertensive medications).
- Yohimbine (raises BP; interactions).
Practical
- Full disclosure list to any clinician managing medications.
- 7–14 day stop before elective surgery for most supplements (specific drugs vary).
- Ask a pharmacist for interaction check when adding a new supplement or medication.
- Best Longevity Interventions Over 70 — Best-of guide.
- Thorne (Onegevity) — Clinic.
- Elysium Health — Company.
- NMN vs NR (NAD+ Precursors) — Comparison.
- Creatine Monohydrate — Intervention.
Related entries
Evidence-based supplements, Longevity in your 70s and beyond.