Intervention
Apigenin
Last updated 2026-07-02· Last reviewed 2026-07-02· 1 min read
Reviewed by the Ultimate Longevity Bible editorial team. Educational reference — not medical advice. See disclaimer.
Mechanism
- CD38 inhibition: CD38 catalyses NAD+ hydrolysis. Age-related CD38 upregulation depletes NAD+. Apigenin inhibits CD38 in vitro.
- Antioxidant / anti-inflammatory: broad flavonoid activity.
- Senolytic-adjacent: preferential clearance of senescent cells in some model systems, though not consistently reproduced.
Evidence
- Preclinical: NAD+ preservation, insulin sensitisation, anti-inflammatory effects in rodents.
- Human: chamomile tea (a dietary source) has weak sleep/anxiolytic evidence; no supplement-level longevity RCTs.
Practical
Dietary sources are safe and cheap. Supplement doses (typically 50–500 mg/day) have unclear pharmacokinetics; bioavailability is limited by extensive first-pass metabolism.
- Fisetin — Intervention.
- Senomorphic vs Senolytic — Concept.
- Senotherapeutic — Concept.