Researcher
Carlos López-Otín
Last updated Sat May 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Background
Carlos López-Otín is Professor of Biochemistry and Molecular Biology at the University of Oviedo, Spain. Studied medicine, then trained in biochemistry; long-time collaborator of Maria Blasco, Linda Partridge, Manuel Serrano, and Guido Kroemer.
Key contributions
- First author of the 2013 "Hallmarks of Aging" Cell paper and the 2023 update (expanding from 9 to 12 hallmarks) — the conceptual scaffold the field organises around.
- Work on the proteolytic system in cancer and aging.
- Progeroid syndromes: characterised the Hutchinson-Gilford progeria syndrome at the molecular level.
- Microbiome and aging: contributions to understanding gut-microbe changes with age.
Books
Calidad de Vida (2019) and La Vida en Cuatro Letras (2019) for Spanish-speaking audiences.
Related entries
Hallmarks of aging, Maria Blasco, Linda Partridge, Loss of proteostasis.
References
- López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 1194–1217 (2013).
- López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: An expanding universe. Cell 186, 243–278 (2023).