Researcher
Vadim Gladyshev
Last updated 2026-05-30· 1 min read
Reviewed by the Ultimate Longevity Bible editorial team. Educational reference — not medical advice. See disclaimer.
Background
Vadim Gladyshev is Professor of Medicine at Harvard Medical School and director of the Center for Redox Medicine at Brigham and Women’s Hospital. Trained as a chemist; transitioned to biology of aging.
Key contributions
- Pan-mammalian DNA-methylation clocks — demonstrating that methylation-aging signatures are conserved across species and can estimate biological age from any mammal.
- Selenoprotein biology — mapped the human selenoproteome and its roles in redox signalling and aging.
- Mitochondrial-thiol biology — mechanistic work on redox switches.
- Founded Retro Biosciences' scientific approach to plasma-factor identification.
Lab focus
- Universal aging biomarkers across mammals.
- Rejuvenation assays (testing interventions against the pan-mammalian clock).
- Plasma-factor screening for age-modifying signals.
- Selenium and redox biology.
- David Sinclair — Researcher.
- George Church — Researcher.
Related entries
Epigenetic clocks, Steve Horvath, Retro Biosciences, Plasma exchange.
References
- Lu, A. T. et al. Universal DNA methylation age across mammalian tissues. Nat. Aging 3, 1144–1166 (2023).