Researcher
Vadim Gladyshev
Last updated Sat May 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Background
Vadim Gladyshev is Professor of Medicine at Harvard Medical School and director of the Center for Redox Medicine at Brigham and Women’s Hospital. Trained as a chemist; transitioned to biology of aging.
Key contributions
- Pan-mammalian DNA-methylation clocks — demonstrating that methylation-aging signatures are conserved across species and can estimate biological age from any mammal.
- Selenoprotein biology — mapped the human selenoproteome and its roles in redox signalling and aging.
- Mitochondrial-thiol biology — mechanistic work on redox switches.
- Founded Retro Biosciences' scientific approach to plasma-factor identification.
Lab focus
- Universal aging biomarkers across mammals.
- Rejuvenation assays (testing interventions against the pan-mammalian clock).
- Plasma-factor screening for age-modifying signals.
- Selenium and redox biology.
Related entries
Epigenetic clocks, Steve Horvath, Retro Biosciences, Plasma exchange.
References
- Lu, A. T. et al. Universal DNA methylation age across mammalian tissues. Nat. Aging 3, 1144–1166 (2023).