Pathway
Calcium Signalling Dysregulation
Last updated 2026-07-02· Last reviewed 2026-07-02· 1 min read
Reviewed by the Ultimate Longevity Bible editorial team. Educational reference — not medical advice. See disclaimer.
Where it matters
- Cardiac aging: SERCA2a downregulation is central to diastolic dysfunction and HFpEF.
- Sarcopenia: RyR1 leakiness in aged muscle drives Ca2+ leak, ROS production, and reduced force.
- Neurons: dysregulated Ca2+ transients contribute to neurodegeneration in Alzheimer's and Parkinson's.
- Mitochondria: excess mitochondrial Ca2+ uptake triggers permeability transition and apoptosis.
Interventions
- Exercise robustly improves cardiac SERCA2a expression.
- Rycals (small molecules stabilising RyR channels) are in trials for heart failure and neurodegeneration.
- No general anti-aging Ca2+-directed therapy exists.
- Mitophagy (PINK1 / Parkin) — Pathway.
- Mitochondrial Unfolded Protein Response (mtUPR) — Pathway.
- Notch Signalling — Pathway.
- GDF-15 — Biomarker.
- Mitobridge (acquired by Astellas) — Company.