Intervention
TB-500 (Thymosin Beta-4)
Last updated 2026-07-02· Last reviewed 2026-07-02· 1 min read
Reviewed by the Ultimate Longevity Bible editorial team. Educational reference — not medical advice. See disclaimer.
What it is
Thymosin beta-4 is a 44-amino-acid endogenous protein that binds G-actin and modulates cytoskeletal dynamics, cell migration, angiogenesis, and inflammation. TB-500 is a synthetic peptide encompassing the actin-binding site, sold to the peptide community.
Evidence
- Preclinical: consistent signals for wound-healing acceleration, cardiac repair post-infarction, and neuroprotection in rodent models.
- Human: essentially no RCT data. Anecdotal use in tendon injury and post-surgical recovery.
- Regulatory: not an approved drug in any major jurisdiction; sold as a "research chemical".
Practical considerations
- Manufacturing quality varies enormously — batch potency and endotoxin contamination are unpredictable outside pharmaceutical-grade compounding pharmacies.
- Injectable route; sterile technique required.
- Prohibited by WADA for competitive athletes.
Longevity relevance
TB-500 is a speculative longevity intervention. The mechanism is plausible; the human data are absent. Not comparable in evidence quality to rapamycin or metformin.