Biomarker
DHEA-S (Dehydroepiandrosterone Sulfate)
Last updated 2026-07-02· Last reviewed 2026-07-02· 1 min read
Reviewed by the Ultimate Longevity Bible editorial team. Educational reference — not medical advice. See disclaimer.
Physiology
- Produced by the zona reticularis of the adrenal cortex.
- Peripheral tissues convert DHEA into androgens and oestrogens.
- Circulating levels: 100–500 μg/dL in young adults, dropping to 30–150 μg/dL by age 70.
Evidence as a biomarker
- Cross-sectional and prospective studies show inverse association with all-cause and cardiovascular mortality in older adults.
- Whether this reflects DHEA-S itself or general adrenal-cortex reserve is unclear.
Supplementation evidence
- Bone density: modest improvement in postmenopausal women.
- Body composition: small effects.
- Sexual function: modest improvement in some men and women with low baseline levels.
- Cognitive function and general aging markers: no consistent benefit.
Practical
- Available OTC in the US as a supplement; prescription-only in most other jurisdictions.
- Typical doses 25–50 mg/day.
- Side effects: androgenic effects (acne, hirsutism in women), oestrogenic effects, and dose-dependent hormonal disruption.
Related entries
HRT (menopause), Testosterone (biomarker), Testosterone replacement.