Biomarker
Eotaxin (CCL11)
Last updated 2026-07-02· Last reviewed 2026-07-02· 1 min read
Reviewed by the Ultimate Longevity Bible editorial team. Educational reference — not medical advice. See disclaimer.
Physiology
- Produced by fibroblasts, endothelial cells, and epithelial cells in response to inflammatory signals.
- Signals via CCR3, expressed on eosinophils and Th2 cells.
- Circulating levels rise with age; further elevated in atopic disease and some cancers.
Aging relevance
- Villeda et al. (2011) identified CCL11 among the plasma factors elevated with age that impair young-mouse cognition after transfer.
- Reducing CCL11 in aged mice partly rescues neurogenesis.
- Interpreted as evidence that circulating pro-aging factors are as important as the loss of young rejuvenating factors.
Clinical measurement
- Not a routine clinical assay.
- Research-only ELISAs available.
- No validated cutoffs for longevity intervention decision-making.
Related entries
Heterochronic parabiosis, Altered intercellular communication, Chronic inflammation.